Chloride potassium symporter 4

Protein-coding gene in the species Homo sapiens
SLC12A4
Identifiers
AliasesSLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4
External IDsOMIM: 604119; MGI: 1309465; HomoloGene: 21056; GeneCards: SLC12A4; OMA:SLC12A4 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for SLC12A4
Genomic location for SLC12A4
Band16q22.1Start67,943,474 bp[1]
End67,969,601 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SLC12A4
Genomic location for SLC12A4
Band8 D3|8 53.06 cMStart106,670,222 bp[2]
End106,692,729 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • ascending aorta

  • stromal cell of endometrium

  • body of uterus

  • Descending thoracic aorta

  • right coronary artery

  • left lobe of thyroid gland

  • left coronary artery

  • tibial nerve

  • tibial arteries
Top expressed in
  • choroid plexus of fourth ventricle

  • molar

  • Epithelium of choroid plexus

  • lip

  • ankle

  • stroma of bone marrow

  • body of femur

  • yolk sac

  • sciatic nerve

  • calvaria
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cation:chloride symporter activity
  • symporter activity
  • transporter activity
  • protein kinase binding
  • potassium:chloride symporter activity
Cellular component
  • lysosomal membrane
  • plasma membrane
  • membrane
  • integral component of membrane
  • integral component of plasma membrane
Biological process
  • ion transport
  • chemical synaptic transmission
  • cell volume homeostasis
  • potassium ion transport
  • potassium ion transmembrane transport
  • transmembrane transport
  • chloride transmembrane transport
  • chloride transport
  • transport
  • chloride ion homeostasis
  • potassium ion homeostasis
  • potassium ion import across plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6560

20498

Ensembl

ENSG00000124067

ENSMUSG00000017765

UniProt

Q9UP95

Q9JIS8

RefSeq (mRNA)

NM_005072
NM_001145961
NM_001145962
NM_001145963
NM_001145964

NM_001253804
NM_009195

RefSeq (protein)

NP_001139433
NP_001139434
NP_001139435
NP_001139436
NP_005063

NP_001240733
NP_033221

Location (UCSC)Chr 16: 67.94 – 67.97 MbChr 8: 106.67 – 106.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124067 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017765 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Further reading

  • Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
  • Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27): 16237–44. doi:10.1074/jbc.271.27.16237. PMID 8663127.
  • Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379.
  • Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation". Am. J. Physiol. 277 (5 Pt 1): C899–912. doi:10.1152/ajpcell.1999.277.5.C899. PMID 10564083.
  • Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl− channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
  • Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052.
  • Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K+–Cl− cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry. 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
  • t
  • e
F-, V-, and A-type ATPase (3.A.2)
H+ (F-type)
H+ (V-type)
A-ATPase
found in Archea
P-type ATPase (3.A.3)
  • 3.A.3.1.2: H+/K+
  • H+/K+ exchanging: ATP4A
  • ATP4B
  • 3.A.3.1.4: H+/K+ transporting, nongastric: ATP12A
  • Other/ungrouped:
  • Na+/K+ – H+
see also ATPase disorders
  • v
  • t
  • e
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
  • Na+/Ca2+ exchanger
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
  • Na+-dependent ascorbic acid transporter
(24):
  • Na+/(Ca2+-K+) exchanger
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
  • basolateral iron transporter
SLC41–48
(41):
(42):
(43):
  • Na+-independent, system-L like amino-acid transporter
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
  • Na+/K+,Cl−
  • Na+/Pi3
  • Na+/Cl−
  • Na+/glucose
  • Na+/I−
  • Cl−/K+
Antiporter (exchanger)
  • Na+/H+
  • Na+/Ca2+
    • Na+/(Ca2+-K+) - Cl−/HCO−
      3       (Band 3)
  • Cl−-formate
  • Cl−-oxalate
see also solute carrier disorders


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e