ATP6V0D2

Protein-coding gene in the species Homo sapiens
ATP6V0D2
Identifiers
AliasesATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDsOMIM: 618072; MGI: 1924415; HomoloGene: 72090; GeneCards: ATP6V0D2; OMA:ATP6V0D2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ATP6V0D2
Genomic location for ATP6V0D2
Band8q21.3Start85,987,323 bp[1]
End86,154,225 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ATP6V0D2
Genomic location for ATP6V0D2
Band4|4 A3Start19,876,841 bp[2]
End19,922,605 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • human kidney

  • buccal mucosa cell

  • amniotic fluid

  • renal medulla

  • testicle

  • rectum

  • tibia

  • muscle of thigh

  • mucosa of transverse colon

  • skin of hip
Top expressed in
  • lumbar spinal ganglion

  • submandibular gland

  • body of femur

  • parotid gland

  • decidua

  • right kidney

  • calvaria

  • human kidney

  • right lung

  • right lung lobe
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • proton transmembrane transporter activity
  • P-type proton-exporting transporter activity
  • proton-transporting ATPase activity, rotational mechanism
Cellular component
  • proton-transporting V-type ATPase, V0 domain
  • endosome
  • phagocytic vesicle membrane
  • membrane
  • apical plasma membrane
  • vacuolar proton-transporting V-type ATPase complex
  • endosome membrane
  • extracellular exosome
  • lysosomal membrane
  • early endosome
  • plasma membrane proton-transporting V-type ATPase complex
Biological process
  • insulin receptor signaling pathway
  • transferrin transport
  • ion transport
  • ion transmembrane transport
  • regulation of macroautophagy
  • phagosome acidification
  • vacuolar transport
  • vacuolar acidification
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

245972

242341

Ensembl

ENSG00000147614

ENSMUSG00000028238

UniProt

Q8N8Y2

Q80SY3

RefSeq (mRNA)

NM_152565

NM_175406

RefSeq (protein)

NP_689778

NP_780615

Location (UCSC)Chr 8: 85.99 – 86.15 MbChr 4: 19.88 – 19.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. [5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. [6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147614 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028238 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
  6. ^ Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–85. doi:10.1359/jbmr.081239. PMC 2672205. PMID 19113919.

External links

Further reading

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