ATP6V1B2

Protein-coding gene in the species Homo sapiens
ATP6V1B2
Identifiers
AliasesATP6V1B2, ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2, ATPase H+ transporting V1 subunit B2, DOOD, ZLS2
External IDsOMIM: 606939; MGI: 109618; HomoloGene: 1279; GeneCards: ATP6V1B2; OMA:ATP6V1B2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ATP6V1B2
Genomic location for ATP6V1B2
Band8p21.3Start20,197,381 bp[1]
End20,226,819 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for ATP6V1B2
Genomic location for ATP6V1B2
Band8|8 B3.3Start69,541,298 bp[2]
End69,566,363 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • monocyte

  • lateral nuclear group of thalamus

  • prefrontal cortex

  • Brodmann area 10

  • orbitofrontal cortex

  • frontal pole

  • Pars compacta

  • dorsolateral prefrontal cortex

  • superior vestibular nucleus
Top expressed in
  • pontine nuclei

  • perirhinal cortex

  • central gray substance of midbrain

  • entorhinal cortex

  • cingulate gyrus

  • CA3 field

  • medial vestibular nucleus

  • inferior colliculus

  • primary motor cortex

  • medial dorsal nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • proton-transporting ATPase activity, rotational mechanism
  • protein binding
  • proton transmembrane transporter activity
  • hydrolase activity
  • ATP binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • proton-transporting V-type ATPase, V1 domain
  • cytosol
  • intracellular membrane-bounded organelle
  • membrane
  • melanosome
  • ruffle
  • myelin sheath
  • plasma membrane
  • microvillus
  • lysosomal membrane
  • extracellular exosome
  • endomembrane system
  • apical plasma membrane
Biological process
  • insulin receptor signaling pathway
  • transferrin transport
  • ion transport
  • ion transmembrane transport
  • ATP metabolic process
  • regulation of macroautophagy
  • phagosome acidification
  • transport
  • proton transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

526

11966

Ensembl

ENSG00000147416

ENSMUSG00000006273

UniProt

P21281

P62814

RefSeq (mRNA)

NM_001693

NM_007509

RefSeq (protein)

NP_001684

NP_031535

Location (UCSC)Chr 8: 20.2 – 20.23 MbChr 8: 69.54 – 69.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.[5][6][7]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.[7]

In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147416 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006273 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bernasconi P, Rausch T, Struve I, Morgan L, Taiz L (Nov 1990). "An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase". J Biol Chem. 265 (29): 17428–31. doi:10.1016/S0021-9258(18)38179-1. PMID 2145275.
  6. ^ Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE (Oct 2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol Cell. 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332.
  7. ^ a b "Entrez Gene: ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

External links

Further reading

  • Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
  • Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
  • Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
  • Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
  • Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
  • Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
  • Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
  • Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
  • Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263. S2CID 17519696.
  • Nelson RD, Guo XL, Masood K, et al. (1992). "Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3541–5. Bibcode:1992PNAS...89.3541N. doi:10.1073/pnas.89.8.3541. PMC 48904. PMID 1373501.
  • Lee BS, Underhill DM, Crane MK, Gluck SL (1995). "Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells". J. Biol. Chem. 270 (13): 7320–9. doi:10.1074/jbc.270.13.7320. PMID 7706273.
  • van Hille B, Richener H, Schmid P, et al. (1994). "Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms". Biochem. J. 303 (1): 191–8. doi:10.1042/bj3030191. PMC 1137575. PMID 7945239.


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