NLRP6 |
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Identifiers |
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Aliases | NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6 |
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External IDs | OMIM: 609650; MGI: 2141990; HomoloGene: 15881; GeneCards: NLRP6; OMA:NLRP6 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11p15.5 | Start | 278,407 bp[1] |
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End | 285,388 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F5 | Start | 140,500,815 bp[2] |
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End | 140,509,105 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - blood
- right lobe of liver
- spleen
- appendix
- duodenum
- left uterine tube
- right lung
- monocyte
- lymph node
- kidney
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| Top expressed in | - Paneth cell
- jejunum
- crypt of lieberkuhn of small intestine
- left lobe of liver
- duodenum
- colon
- ileum
- intestinal villus
- left colon
- proximal tubule
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- vasopressin receptor activity
- ATP binding
| Cellular component | - cytoplasm
- nuclear membrane
- membrane
- plasma membrane
- inflammasome complex
- nucleus
| Biological process | - response to bacterium
- immune system process
- wound healing
- regulation of mucus secretion
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- negative regulation of immune response
- regulation of autophagy
- negative regulation of toll-like receptor signaling pathway
- negative regulation of inflammatory response to antigenic stimulus
- regulation of inflammatory response
- negative regulation of MAPK cascade
- negative regulation of ERK1 and ERK2 cascade
- innate immune response
- inflammatory response
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 0.28 – 0.29 Mb | Chr 7: 140.5 – 140.51 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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