NLRP6

Protein-coding gene in the species Homo sapiens
NLRP6
Identifiers
AliasesNLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDsOMIM: 609650; MGI: 2141990; HomoloGene: 15881; GeneCards: NLRP6; OMA:NLRP6 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NLRP6
Genomic location for NLRP6
Band11p15.5Start278,407 bp[1]
End285,388 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NLRP6
Genomic location for NLRP6
Band7|7 F5Start140,500,815 bp[2]
End140,509,105 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • right lobe of liver

  • spleen

  • appendix

  • duodenum

  • left uterine tube

  • right lung

  • monocyte

  • lymph node

  • kidney
Top expressed in
  • Paneth cell

  • jejunum

  • crypt of lieberkuhn of small intestine

  • left lobe of liver

  • duodenum

  • colon

  • ileum

  • intestinal villus

  • left colon

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • vasopressin receptor activity
  • ATP binding
Cellular component
  • cytoplasm
  • nuclear membrane
  • membrane
  • plasma membrane
  • inflammasome complex
  • nucleus
Biological process
  • response to bacterium
  • immune system process
  • wound healing
  • regulation of mucus secretion
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • negative regulation of immune response
  • regulation of autophagy
  • negative regulation of toll-like receptor signaling pathway
  • negative regulation of inflammatory response to antigenic stimulus
  • regulation of inflammatory response
  • negative regulation of MAPK cascade
  • negative regulation of ERK1 and ERK2 cascade
  • innate immune response
  • inflammatory response
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

171389

101613

Ensembl

ENSG00000174885

ENSMUSG00000038745

UniProt

P59044

Q91WS2

RefSeq (mRNA)

NM_001276700
NM_138329

NM_001081389
NM_133946

RefSeq (protein)

NP_001263629
NP_612202

NP_598707

Location (UCSC)Chr 11: 0.28 – 0.29 MbChr 7: 140.5 – 140.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174885 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038745 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.

Further reading

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
  • Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. S2CID 7730963.
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
  • Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
  • v
  • t
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CARD domain containing
Pyrin domain containingApoptosis inhibitory protein
  • NAIP
Family member X1


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