Guanoclor
Chemical compound
- C02CC05 (WHO)
- 2-{[2-(2,6-Dichlorophenoxy)ethyl]amino}guanidine
- 5001-32-1
- 71835
- 64857
- M4HBT852YO
- DTXSID10198184
- Interactive image
- C1=CC(=C(C(=C1)Cl)OCCNNC(=N)N)Cl
InChI
- InChI=1S/C9H12Cl2N4O/c10-6-2-1-3-7(11)8(6)16-5-4-14-15-9(12)13/h1-3,14H,4-5H2,(H4,12,13,15)
- Key:XIHXRRMCNSMUET-UHFFFAOYSA-N
Guanoclor (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.[1]
Synthesis
When β-(2,6-dichlorophenoxy)ethyl bromide (1) is reacted with hydrazine to give 2, and this is reacted with S-methylthiourea, guanochlor (3) results.[2][3]
References
- ^ Vigne P, Lazdunski M, Frelin C (January 1989). "Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes". European Journal of Pharmacology. 160 (2): 295–8. doi:10.1016/0014-2999(89)90503-7. PMID 2527160.
- ^ Durant GJ, Smith GM, Spickett RG, Wright SH (January 1966). "Biologically active guanidines and related compounds. II. Some antiinflammatory aminoguanidines". Journal of Medicinal Chemistry. 9 (1): 22–7. doi:10.1021/jm00319a005. PMID 5958955.
- ^ Prepn of free base and sulfate: BE 629613 (1963 to Pfizer), C.A. 60, 14437d (1964).
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(antagonize α-adrenergic
vasoconstriction)
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Peripheral |
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Serotonin receptor antagonists | |
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Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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