Beta1-adrenergic agonist

Beta₁-adrenergic agonists, also known as Beta₁-adrenergic receptor agonists, are a class of drugs that bind selectively to the beta-1 adrenergic receptor. As a result, they act more selectively upon the heart. Beta-adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine. The effect of B-adrenoceptors is cardiac stimulation, such as increased heart rate, heart contractility, heart conduction velocity and heart relaxation.^[1]

Examples

Examples include:

denopamine^[2]^[3] β₁ agonist
dobutamine β₁>β₂ agonist
xamoterol β₁ partial agonist
epinephrine
- Epinephrine is a non-selective beta agonist, this means it also stimulates the beta 2 adrenergic receptor. Therefore, epinephrine is a Beta2-adrenergic agonist.
Isoprenaline

References

^ Sakuma, Tsutomu; Hida, Mieko; Nambu, Yoshihiro; Osanai, Kazuhiro; Toga, Hirohisa; Takahashi, Keiji; Ohya, Nobuo; Inoue, Masao; Watanabe, Yoh (2001). "Beta1-Adrenergic Agonist Is a Potent Stimulator of Alveolar Fluid Clearance in Hyperoxic Rat Lungs". The Japanese Journal of Pharmacology. 85 (2): 161–166. doi:10.1254/jjp.85.161. ISSN 0021-5198. PMID 11286398.
^ Sakuma T, Hida M, Nambu Y, et al. (February 2001). "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Jpn. J. Pharmacol. 85 (2): 161–6. doi:10.1254/jjp.85.161. PMID 11286398.
^ Nishio R, Matsumori A, Shioi T, et al. (September 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". J. Am. Coll. Cardiol. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223. PMID 9741531.

Pharmacomodulation

Types

♦ Enzyme: Inducer
Inhibitor

♦ Ion channel: Opener
Blocker

♦ Transporter [Reuptake vs Efflux]: Enhancer (RE)
Inhibitor (RI)
Releaser (RA)

♦ Miscellaneous: Precursor
Cofactor

Classes

Enzyme

see Enzyme inhibition

Ion channel

See Ion channel modulators

Receptor &
transporter

BA/M

Adrenergic	Adrenergic receptor agonist (α β (1 2)) Adrenergic receptor antagonist (α (1 2) β) Norepinephrine reuptake inhibitor (NRI)
Dopaminergic	Dopamine receptor agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI)
Histaminergic	Histamine receptor agonist Histamine receptor antagonist (H₁ H₂ H₃)
Serotonergic	Serotonin receptor agonist Serotonin receptor antagonist (5-HT₃) Serotonin reuptake inhibitor (SRI)

GABAergic	GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor (GRI)
Glutamatergic	Glutamate receptor agonist (AMPA) Glutamate receptor antagonist (NMDA) Glutamate reuptake inhibitor