UGT1A10

UGT1A10
Identifikatori
AlijasiUGT1A10
Spoljašnji IDOMIM: 606435 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A10
Genska lokacija (miš)
Chromosome 1 (mouse)
Hr.Chromosome 1 (mouse)[1]
Chromosome 1 (mouse)
Genomska lokacija za UGT1A10
Genomska lokacija za UGT1A10
Band1|1 DStart87,998,522 bp[1]
Kraj88,146,719 bp[1]
Genska ontologija
Molecular function transferase activity
retinoic acid binding
hexosyltransferase activity
protein homodimerization activity
glycosyltransferase activity
protein heterodimerization activity
enzyme binding
protein kinase C binding
glucuronosyltransferase activity
UDP-glycosyltransferase activity
Cellular component саставни део мембране
мембрана
intracellular membrane-bounded organelle
ендоплазматични ретикулум
endoplasmic reticulum membrane
Biological process negative regulation of cellular glucuronidation
xenobiotic glucuronidation
flavone metabolic process
метаболизам
negative regulation of glucuronosyltransferase activity
negative regulation of fatty acid metabolic process
Glukuronidacija
flavonoid glucuronidation
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

54575

394434

Ensembl

ENSG00000242515

ENSMUSG00000090175

UniProt

Q9HAW8

Q62452

RefSeq (mRNA)

NM_019075

NM_201644

RefSeq (protein)

NP_061948

NP_964006

Location (UCSC)n/aChr 1: 88 – 88.15 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-glukuronoziltransferaza 1-10 je enzim koji je kod ljudi kodiran genom UGT1A10.[4][5][6]

Interaktivna mapa putanja

Kliknite na gene, proteine i metabolite u nastavku za veze s odgovarajućim člancima. [§ 1]

[[File:
IrinotecanPathway_WP46359idi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članak
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IrinotecanPathway_WP46359idi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članakidi u članak
|{{{bSize}}}px|alt=Irinotekanski put edit]]
Irinotekanski put edit
  1. ^ The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”. 

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001. CS1 одржавање: Формат датума (веза)
  5. ^ Mojarrabi B, Mackenzie PI (октобар 1997). „The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid”. Biochem Biophys Res Commun. 238 (3): 775—8. PMID 9325166. doi:10.1006/bbrc.1997.7388. CS1 одржавање: Формат датума (веза)
  6. ^ „Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10”. 

Literatura

  • Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annu. Rev. Pharmacol. Toxicol. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581. 
  • Tukey RH, Strassburg CP (2001). „Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract”. Mol. Pharmacol. 59 (3): 405—14. PMID 11179432. S2CID 21500183. doi:10.1124/mol.59.3.405. 
  • King CD, Rios GR, Green MD, Tephly TR (2001). „UDP-glucuronosyltransferases”. Curr. Drug Metab. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171. 
  • Harding D, Jeremiah SJ, Povey S, Burchell B (1990). „Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1”. Ann. Hum. Genet. 54 (Pt 1): 17—21. PMID 2108603. S2CID 35661967. doi:10.1111/j.1469-1809.1990.tb00356.x. 
  • van Es HH; Bout A; Liu J; et al. (1993). „Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37”. Cytogenet. Cell Genet. 63 (2): 114—6. PMID 8467709. doi:10.1159/000133513. 
  • Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). „Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue”. Mol. Pharmacol. 52 (2): 212—20. PMID 9271343. S2CID 37098463. doi:10.1124/mol.52.2.212. 
  • Mojarrabi B, Mackenzie PI (1998). „Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon”. Biochem. Biophys. Res. Commun. 247 (3): 704—9. PMID 9647757. doi:10.1006/bbrc.1998.8843. 
  • Strassburg CP; Strassburg A; Nguyen N; et al. (1999). „Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus”. Biochem. J. 338 (2): 489—98. PMC 1220077 Слободан приступ. PMID 10024527. doi:10.1042/0264-6021:3380489. 
  • Cheng Z, Radominska-Pandya A, Tephly TR (1999). „Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10”. Drug Metab. Dispos. 27 (10): 1165—70. PMID 10497143. 
  • Strassburg CP; Kneip S; Topp J; et al. (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200 Слободан приступ. 
  • Gong QH; Cho JW; Huang T; et al. (2001). „Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus”. Pharmacogenetics. 11 (4): 357—68. PMID 11434514. doi:10.1097/00008571-200106000-00011. 
  • Zheng Z, Fang JL, Lazarus P (2002). „Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues”. Drug Metab. Dispos. 30 (4): 397—403. PMID 11901093. doi:10.1124/dmd.30.4.397. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Jinno H; Saeki M; Tanaka-Kagawa T; et al. (2003). „Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10”. Drug Metab. Dispos. 31 (5): 528—32. PMID 12695339. doi:10.1124/dmd.31.5.528. 
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2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze