S1PR1

Sfingozin-1-fosfatni receptor 1
Struktura SIPR1-lizozim fuzije 3v2y[1]
Dostupne strukture
3V2W​, 3V2Y​
Identifikatori
Simboli S1PR1; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1
Vanjski ID OMIM: 601974 MGI: 1096355 HomoloGene: 1071 IUPHAR: S1P1 GeneCards: S1PR1 Gene
Ontologija gena
Molekularna funkcija • aktivnost G-protein spregnutog receptora
• aktivnost sfingozin-1-fosfat receptora
• vezivanje sfingolipida
Celularna komponenta • ćelijska membrana
• spoljašnja strana ćelijske membrane
• integralno sa membranom
Biološki proces • angiogeneza
• ćelijska adhezija
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1901 13609
Ensembl ENSG00000170989 ENSMUSG00000045092
UniProt P21453 O08530
RefSeq (mRNA) NM_001400.4 NM_007901.5
RefSeq (protein) NP_001391.2 NP_031927.2
Lokacija (UCSC) Chr 1:
101.7 - 101.71 Mb		 Chr 3:
115.41 - 115.42 Mb
PubMed pretraga [1] [2]

S1PR1 (sfingozin-1-fosfatni receptor 1, S1P1, EDG1, endotelni diferencijacioni gen 1) je protein koji je kod ljudi kodiran S1PR1 genom. S1P1 je G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin-1-fosfat (S1P).

Funkcija

Ovaj protein je visoko izražen u endotelnim ćelijama. On vezuje sfingozin-1-fosfat sa visokim afinitetom i specifičnošću, i smatra se da učestvuje u procesima koji regulišu diferencijaciju endotelnih ćelija. Aktivacija ovog receptora indukuje međućelijsku adheziju.[2]

Interakcije

S1PR1 formira interakcije sa 5-HT1A receptorom,[3] GNAI1[4] i GNAI3.[4]

Vidi još

Reference

  1. ^ Hanson, M. A.; Roth, C. B.; Jo, E.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S. M. (2012). „Crystal Structure of a Lipid G Protein-Coupled Receptor”. Science. 335 (6070): 851. doi:10.1126/science.1215904. 
  2. ^ „Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1”. 
  3. ^ Salim, Kamran; Fenton Tim; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. United States. 277 (18): 15482—5. ISSN 0021-9258. PMID 11854302. doi:10.1074/jbc.M201539200. 
  4. ^ а б Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272. 

Literatura

  • Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 54—60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x. 
  • Igarashi Y (2002). „[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]”. Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 476—9. PMID 11915345. 
  • Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496—502. PMID 11915348. 
  • Takuwa Y, Takuwa N, Sugimoto N (2003). „The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.”. J. Biochem. 131 (6): 767—71. PMID 12038970. 
  • Wang D; Zhao Z; Caperell-Grant A; et al. (2008). „S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.”. Mol Cancer Ther. 7 (7): 1993—2002. PMID 18645009. 
  • Hla T, Maciag T (1990). „An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.”. J. Biol. Chem. 265 (16): 9308—13. PMID 2160972. 
  • Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272—9. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • An S; Bleu T; Huang W; et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”. FEBS Lett. 417 (3): 279—82. PMID 9409733. doi:10.1016/S0014-5793(97)01301-X. 
  • Lee MJ; Van Brocklyn JR; Thangada S; et al. (1998). „Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.”. Science. 279 (5356): 1552—5. PMID 9488656. doi:10.1126/science.279.5356.1552. 
  • Lee MJ; Thangada S; Liu CH; et al. (1998). „Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.”. J. Biol. Chem. 273 (34): 22105—12. PMID 9705355. doi:10.1074/jbc.273.34.22105. 
  • Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem. 274 (27): 18997—9002. PMID 10383399. doi:10.1074/jbc.274.27.18997. 
  • Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351—8. PMID 10488065. doi:10.1074/jbc.274.39.27351. 
  • Lee MJ; Thangada S; Claffey KP; et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”. Cell. 99 (3): 301—12. PMID 10555146. doi:10.1016/S0092-8674(00)81661-X. 
  • Igarashi J, Michel T (2000). „Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.”. J. Biol. Chem. 275 (41): 32363—70. PMID 10921915. doi:10.1074/jbc.M003075200. 
  • Parrill AL; Wang D; Bautista DL; et al. (2001). „Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.”. J. Biol. Chem. 275 (50): 39379—84. PMID 10982820. doi:10.1074/jbc.M007680200. 
  • Liu Y; Wada R; Yamashita T; et al. (2000). „Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.”. J. Clin. Invest. 106 (8): 951—61. PMC 314347 Слободан приступ. PMID 11032855. doi:10.1172/JCI10905. 
  • Murphy WJ; Eizirik E; Johnson WE; et al. (2001). „Molecular phylogenetics and the origins of placental mammals.”. Nature. 409 (6820): 614—8. PMID 11214319. doi:10.1038/35054550. 
  • Hobson JP; Rosenfeldt HM; Barak LS; et al. (2001). „Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.”. Science. 291 (5509): 1800—3. PMID 11230698. doi:10.1126/science.1057559. 
  • Lee MJ; Thangada S; Paik JH; et al. (2001). „Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.”. Mol. Cell. 8 (3): 693—704. PMID 11583630. doi:10.1016/S1097-2765(01)00324-0. 

Spoljašnje veze

  • „Lysophospholipid Receptors: S1P1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 07. 01. 2015. г. 
  • Lysophospholipid+receptors на US National Library of Medicine Medical Subject Headings (MeSH)
  • п
  • р
  • у
Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni