Nitrilaza

Nitrilaza
Identifikatori
EC broj3.5.5.1
CAS broj9024-90-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Nitrilaza (EC 3.5.5.1, acetonitrilaza, benzonitrilaza) je enzim sa sistematskim imenom nitril aminohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

nitril + 2H2O {\displaystyle \rightleftharpoons } karboksilat + NH3

Ovaj enzim deluje na širok opseg aromatičnih nitrila.

Reference

  1. ^ Harper, D.B. (1977). „Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216”. Biochem. J. 165: 309—319. PMID 21655. 
  2. ^ Thimann, K.V. & Mahadevan, S. (1964). „Nitrilase. I. Occurrence, preparation, and general properties of the enzyme”. Arch. Biochem. Biophys. 105: 133—141. PMID 14165487. 
  3. ^ Pace, H.C. & Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.—001.9. PMID 11380987. 

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
  • William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

  • Nitrilase на US National Library of Medicine Medical Subject Headings (MeSH)
  • п
  • р
  • у
Hidrolaze: ugljenično-azotne nepeptidne (EC 3.5)
3.5.1: Linearni amidi /
Amidohidrolaze3.5.2: Cyclic amides/
Amidohidrolaze3.5.3: Linear amidines/
Ureohidrolaze3.5.4: Cyclic amidines/
Aminohidrolaze3.5.5: Nitrili/
Aminohidrolaze
  • Nitrilaza
3.5.99: Drugi
  • п
  • р
  • у
Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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