Laktoza sintaza
| Laktoza sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Laktoza sintaza monomer, Bos taurus + alpha-lactalbumin, Mus musculus | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.1.22 | ||||||||
| CAS broj | 2604493 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Laktoza sintaza (EC 2.4.1.22, UDP-galaktoza glukoza galaktoziltransferaza, N-acetillaktozaminska sintaza, uridin difosfogalaktoza-glukoza galaktoziltransferaza, laktozna sintetaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktotransferaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + D-glukoza UDP + laktoza
Ovaj enzim je kompleks dva proteina, A i B. U odsustvu B proteina (alfa-laktalbumina), ovaj enzim katalizuje transfer galaktoze sa UDP-alfa-D-galaktoze na N-acetilglukozamin (EC 2.4.1.90, N-acetilaktozamin sintaza).
Reference
- ↑ Fitzgerald, D.K., Brodbeck, U., Kiyosawa, I., Mawal, R., Colvin, B. and Ebner, K.E. (1970). „α-Lactalbumin and the lactose synthetase reaction”. J. Biol. Chem. 245: 2103-2108. PMID 5440844.
- ↑ Hill, R.L. and Brew, K. (1975). „Lactose synthetase”. Adv. Enzymol. Relat. Areas Mol. Biol. 43: 411-490. PMID 812340.
- ↑ Watkins, W.M. and Hassid, W.Z. (1962). „The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands”. J. Biol. Chem. 237: 1432-1440. PMID 14005251.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Lactose+synthase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
