Pax6

PAX6

Structures disponibles

PDB

Recherche d'orthologue: PDBe RCSB

Identifiants PDB
2CUE, 6PAX

Identifiants

Aliases

PAX6

IDs externes

OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6

Position du gène (Homme)

Chr.	Chromosome 11 humain^[1]

Locus	11p13	Début	31,784,779 bp^[1]
Locus	11p13	Fin	31,818,062 bp^[1]

Position du gène (Souris)

Chr.	Chromosome 2 (souris)^[2]

Locus	2 E3\|2 55.31 cM	Début	105,499,245 bp^[2]
Locus	2 E3\|2 55.31 cM	Fin	105,527,709 bp^[2]

Expression génétique

Bgee

Humain

Souris (orthologue)

Fortement exprimé dans

palpebral conjunctiva

ventricular zone

cellule bêta

paraflocculus of cerebellum

éminence ganglionnaire

Vermis du cervelet

right hemisphere of cerebellum

pont

external globus pallidus

Region I of hippocampus proper

Fortement exprimé dans

neural layer of retina

corneal stroma

ventricular zone

cristallin

épithélium cornéen

iris

epithelium of lens

îlot de Langerhans

corps ciliaire

conjunctival fornix

Plus de données d'expression de référence

BioGPS


Plus de données d'expression de référence

Gene Ontology
Fonction moléculaire	liaison protéique liaison ADN sequence-specific DNA binding ubiquitin-protein transferase activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific liaison de chromatine DNA-binding transcription factor activity transcription factor binding protein kinase binding ubiquitin protein ligase binding liaison d'histone acétyltransférase co-SMAD binding R-SMAD binding HMG box domain binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific
Composant cellulaire	cytoplasme noyau nucléoplasme cytosol intracellulaire
Processus biologique	développement de l'œil blood vessel development morphogenèse d'un organe animal regulation of transcription, DNA-templated glucose homeostasis transcription, DNA-templated central nervous system development response to wounding différenciation cellulaire cornea development in camera-type eye negative regulation of neurogenesis vue iris morphogenesis développent d'un organisme multicellulaire neuron fate commitment Ubiquitination negative regulation of transcription by RNA polymerase II establishment of mitotic spindle orientation cell fate determination migration d'un neurone negative regulation of protein phosphorylation positive regulation of neuroblast proliferation lens development in camera-type eye régionalisation type B pancreatic cell differentiation pancreatic A cell development regulation of transcription by RNA polymerase II transcription by RNA polymerase II hedgehog axonogenesis Guidage axonal développement cérébral salivary gland morphogenesis negative regulation of cell population proliferation regulation of asymmetric cell division dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation régulation de l'expression des gènes positive regulation of gene expression pallium development oligodendrocyte cell fate specification cerebral cortex regionalization forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation telencephalon regionalization pituitary gland development habenula development signal transduction involved in regulation of gene expression keratinocyte differentiation regulation of cell migration positive regulation of epithelial cell differentiation forebrain development lacrimal gland development protein localization to organelle eye photoreceptor cell development camera-type eye development cell fate commitment negative regulation of neuron differentiation régulation positive de la transcription dépendante de l'ADN positive regulation of transcription by RNA polymerase II regulation of timing of cell differentiation embryonic camera-type eye morphogenesis astrocyte differentiation negative regulation of epithelial cell proliferation régulation de la neurogenèse retina development in camera-type eye cellular response to leukemia inhibitory factor negative regulation of neural precursor cell proliferation positive regulation of core promoter binding
Sources:Amigo / QuickGO

Orthologues

Espèces

Homme

Souris

Entrez


5080


18508

Ensembl


ENSG00000007372


ENSMUSG00000027168

UniProt


P26367


P63015

RefSeq (mRNA)

NM_000280 NM_001127612 NM_001258462 NM_001258463 NM_001258464
NM_001258465 NM_001310158 NM_001310159 NM_001310160 NM_001310161 NM_001604

NM_001244198 NM_001244200 NM_001244201 NM_001244202 NM_013627
NM_001310144 NM_001310145 NM_001310146

RefSeq (protéine)

NP_000271
NP_001121084
NP_001245391
NP_001245392
NP_001245393

NP_001245394
NP_001297087
NP_001297088
NP_001297089
NP_001297090
NP_001595
NP_001355816
NP_001355817
NP_001355818
NP_001355819
NP_001355820
NP_001355821
NP_001355822
NP_001355823
NP_001355828
NP_001355829
NP_001355830
NP_001355831
NP_001355832
NP_001355833
NP_001355834
NP_001355835
NP_001355836
NP_001355837
NP_001355838
NP_001355839
NP_001355840
NP_001355841
NP_001355842
NP_001355843
NP_001355844
NP_001355845
NP_001355846
NP_001355847
NP_001355848
NP_001355849
NP_001355850
NP_001355851
NP_001355852
NP_001355853
NP_001355854
NP_001355855
NP_001355856
NP_001355857
NP_001355858
NP_001355859

NP_001231127 NP_001231129 NP_001231130 NP_001231131 NP_001297073
NP_001297074 NP_001297075 NP_038655

Localisation (UCSC)

Chr 11: 31.78 – 31.82 Mb

Chr 2: 105.5 – 105.53 Mb

Publication PubMed

^[3]

^[4]

Wikidata

Voir/Editer Humain

Voir/Editer Souris

La protéine paired box 6 (Pax6) est un facteur de transcription notamment impliqué dans le développement des yeux. Elle est codée par le gène PAX6 situé sur le chromosome 11 humain.

Notes et références

(en) Cet article est partiellement ou en totalité issu de l’article de Wikipédia en anglais intitulé « PAX6 » (voir la liste des auteurs).

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000027168 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine