Post | Minister | Term | Party |
| Prime Minister | Gen. Jan Smuts | 1939 | 1948 | UP |
Minister of Defence |
Minister of External Affairs |
| Deputy Prime Minister | The Hon. J. F. H. Hofmeyr MP | 1943 | 1948 | UP |
| Minister of Agriculture and Forestry | The Hon. J. G. N. Strauss MP | 1944 | 1948 | UP |
| The Hon. W. R. Collins MP | 1938 | 1944 | UP |
| Minister of Economic Development (renamed in 1944) | The Hon. Sidney Waterson MP | 1941 | 1948 | UP |
| Minister of Education | The Hon. J. F. H. Hofmeyr MP | 1939 | 1948 | UP |
| Minister of Finance | The Hon. J. F. H. Hofmeyr MP | 1939 | 1948 | UP |
| Minister of Interior Affairs | | The Hon. C. F. Clarkson MP | | 1943 | 1948 | UP |
| Minister of Justice | The Hon. Harry Lawrence MP | 1945 | 1948 | UP |
| The Hon. C. F. Steyn MP | 1939 | 1945 | UP |
| Minister of Labour | The Hon. C. F. Steyn MP | 1945 | 1948 | UP |
| The Hon. Walter Madeley MP | 1939 | 1945 | Labour |
| Minister of Lands and Irrigation | | 1939 | 1948 | UP |
| Minister of Mines | The Hon. C. F. Stallard MP | 1939 | 1945 | Dominion |
| Minister of Native Affairs | | 1943 | 1948 | UP |
| Minister of Posts and Telegraphs | | The Hon. C. F. Clarkson MP | | 1933 | 1945 | UP |
| Minister of Public Works | | The Hon. C. F. Clarkson MP | | 1933 | 1945 | UP |
| Minister of Transport (renamed in 1944) | The Hon. F. C. Sturrock MP | 1939 | 1948 | UP |
| Minister of Welfare and Demobilisation (merger of Social Welfare and Public Health in 1944) | The Hon. Harry Lawrence MP | 1939 | 1948 | UP |