TUBG2

Protein-coding gene in the species Homo sapiens
TUBG2
Identifiers
AliasesTUBG2, tubulin gamma 2
External IDsOMIM: 605785; MGI: 2144208; HomoloGene: 69216; GeneCards: TUBG2; OMA:TUBG2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TUBG2
Genomic location for TUBG2
Band17q21.2Start42,659,284 bp[1]
End42,667,006 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TUBG2
Genomic location for TUBG2
Band11|11 DStart101,046,733 bp[2]
End101,052,613 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • right hemisphere of cerebellum

  • anterior cingulate cortex

  • prefrontal cortex

  • body of pancreas

  • amygdala

  • Brodmann area 9

  • C1 segment

  • nucleus accumbens

  • caudate nucleus
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • incisor

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • dorsomedial hypothalamic nucleus

  • superior colliculus

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • structural molecule activity
  • GTPase activity
  • structural constituent of cytoskeleton
Cellular component
  • cytoplasm
  • microtubule cytoskeleton
  • microtubule organizing center
  • cytoplasmic microtubule
  • cytosol
  • centrosome
  • spindle microtubule
  • gamma-tubulin complex
  • pericentriolar material
  • cytoskeleton
  • microtubule
  • nucleus
  • spindle
Biological process
  • cytoplasmic microtubule organization
  • microtubule nucleation
  • microtubule-based process
  • mitotic sister chromatid segregation
  • meiotic spindle organization
  • microtubule cytoskeleton organization
  • mitotic cell cycle
  • mitotic spindle organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27175

103768

Ensembl

ENSG00000037042

ENSMUSG00000045007

UniProt

Q9NRH3

Q8VCK3

RefSeq (mRNA)

NM_016437
NM_001320509

NM_134028

RefSeq (protein)

NP_001307438
NP_057521

NP_598789

Location (UCSC)Chr 17: 42.66 – 42.67 MbChr 11: 101.05 – 101.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000037042 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045007 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TUBG2 tubulin, gamma 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Tassin AM, Celati C, Moudjou M, Bornens M (1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J. Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.
  • Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. hdl:10261/135387. PMID 10840040.
  • Wise DO, Krahe R, Oakley BR (2000). "The gamma-tubulin gene family in humans". Genomics. 67 (2): 164–70. doi:10.1006/geno.2000.6247. PMID 10903841.
  • Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • v
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  • 1z5v: Crystal structure of human gamma-tubulin bound to GTPgammaS
    1z5v: Crystal structure of human gamma-tubulin bound to GTPgammaS
  • 1z5w: Crystal Structure of gamma-tubulin bound to GTP
    1z5w: Crystal Structure of gamma-tubulin bound to GTP


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