TACC1

Protein-coding gene in the species Homo sapiens
TACC1
Identifiers
AliasesTACC1, Ga55, transforming acidic coiled-coil containing protein 1
External IDsOMIM: 605301; MGI: 2443510; HomoloGene: 4575; GeneCards: TACC1; OMA:TACC1 - orthologs
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[1]
Chromosome 8 (mouse)
Genomic location for TACC1
Genomic location for TACC1
Band8|8 A2Start25,644,568 bp[1]
End25,746,604 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • gastrula

  • otolith organ

  • utricle

  • decidua

  • uterus

  • dorsal striatum

  • brown adipose tissue

  • nucleus accumbens

  • adrenal gland

  • prefrontal cortex
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nuclear receptor binding
  • estrogen receptor binding
  • glucocorticoid receptor binding
  • retinoic acid receptor binding
  • peroxisome proliferator activated receptor binding
  • retinoid X receptor binding
  • thyroid hormone receptor binding
Cellular component
  • midbody
  • cytoskeleton
  • membrane
  • nucleus
  • microtubule organizing center
  • cytoplasm
  • microtubule cytoskeleton
Biological process
  • cerebral cortex development
  • cell division
  • cell cycle
  • cell population proliferation
  • microtubule cytoskeleton organization
  • mitotic spindle organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6867

320165

Ensembl

ENSG00000147526

ENSMUSG00000065954

UniProt

O75410

Q6Y685

RefSeq (mRNA)

NM_001122824
NM_001146216
NM_006283
NM_001330521

NM_177089
NM_199323

RefSeq (protein)
NP_001116296
NP_001139688
NP_001317450
NP_006274
NP_001339707

NP_001339708
NP_001339709
NP_001339710
NP_001339711
NP_001339712
NP_001339713
NP_001339714
NP_001339715
NP_001339716
NP_001339717
NP_001339718
NP_001339719
NP_001339720
NP_001339721
NP_001339722
NP_001339723
NP_001339724
NP_001339725
NP_001339726
NP_001339727
NP_001339728
NP_001339729
NP_001339730
NP_001339731
NP_001339732
NP_001339733

NP_796063
NP_955355
NP_001389770
NP_001389771
NP_001389772

Location (UCSC)n/aChr 8: 25.64 – 25.75 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.[4]

Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.[4]

Interactions

TACC1 has been shown to interact with:

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000065954 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1".
  5. ^ a b Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (Jun 2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709. S2CID 23605902.
  6. ^ a b c d Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
  7. ^ Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I (Feb 2009). "Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2". Cancer Res. 69 (3): 1125–34. doi:10.1158/0008-5472.CAN-08-2134. PMID 19176389.
  8. ^ Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
  9. ^ a b Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Further reading

  • Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma. 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID 12389629. S2CID 2098614.
  • Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
  • Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene. 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627. S2CID 24062786.
  • Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
  • Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
  • Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
  • Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
  • Line A, Slucka Z, Stengrevics A, Li G, Rees RC (2003). "Altered splicing pattern of TACC1 mRNA in gastric cancer". Cancer Genet. Cytogenet. 139 (1): 78–83. doi:10.1016/S0165-4608(02)00607-6. PMID 12547166.
  • Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
  • Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. S2CID 22590391.
  • Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709. S2CID 23605902.
  • Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Lauffart B, Dimatteo A, Vaughan MM, Cincotta MA, Black JD, Still IH (2007). "Temporal and spatial expression of TACC1 in the mouse and human". Dev. Dyn. 235 (6): 1638–47. doi:10.1002/dvdy.20724. PMID 16496324. S2CID 26231825.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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