Retinoid receptor
Nuclear receptors that bind to retinoids
Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis.[1]
Subtypes include:
- Retinoic acid receptors (RARs)
- Retinoid X receptors (RXRs)
- RAR-related orphan receptors (RORs)
References
- ^ Dyall SC, Michael GJ, Michael-Titus AT (2010). "Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats". Journal of Neuroscience Research. 88 (10): 2091–2102. doi:10.1002/jnr.22390. PMID 20336774. S2CID 1620277.
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Transcription factors and intracellular receptors
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(4) β-Scaffold factors with minor groove contacts | |||||||||||||||||||
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(0) Other transcription factors | |||||||||
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see also transcription factor/coregulator deficiencies
