QKI

Protein

QKI

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4JVH

Identifiers

Aliases

QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding

External IDs

OMIM: 609590; MGI: 97837; HomoloGene: 11059; GeneCards: QKI; OMA:QKI - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q26	Start	163,414,000 bp^[1]
Band	6q26	End	163,578,592 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 A1\|17 7.75 cM	Start	10,421,530 bp^[2]
Band	17 A1\|17 7.75 cM	End	10,538,783 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

dorsal motor nucleus of vagus nerve

corpus callosum

inferior olivary nucleus

inferior ganglion of vagus nerve

external globus pallidus

pars reticulata

subthalamic nucleus

superior vestibular nucleus

internal globus pallidus

Top expressed in

Gonadal ridge

otic placode

saccule

sciatic nerve

left lung lobe

deep cerebellar nuclei

substantia nigra

cumulus cell

lateral geniculate nucleus

tail of embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	SH3 domain binding protein binding nucleic acid binding mRNA binding RNA binding
Cellular component	cytoplasm nucleus synapse
Biological process	cell differentiation mRNA transport mRNA processing vasculogenesis multicellular organism development axon ensheathment muscle cell differentiation positive regulation of gene expression long-chain fatty acid biosynthetic process RNA splicing spermatid development myelination 3'-UTR-mediated mRNA destabilization regulation of translation transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9444


19317

Ensembl


ENSG00000112531


ENSMUSG00000062078

UniProt


Q96PU8


Q9QYS9

RefSeq (mRNA)


NM_001301085 NM_006775 NM_206853 NM_206854 NM_206855


NM_001159516 NM_001159517 NM_021881

RefSeq (protein)


NP_001288014 NP_006766 NP_996735 NP_996736 NP_996737


NP_001152988 NP_001152989 NP_068681

Location (UCSC)

Chr 6: 163.41 – 163.58 Mb

Chr 17: 10.42 – 10.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.^[5]^[6]

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.^[7] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .^[8] Two more new members are KHDRBS3^[9] and KHDRBS2.^[10]

The QKI gene is implicated as being important in schizophrenia,^[11]^[12] and QKI controls translation of many oligodendrocyte-related genes.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112531 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062078 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)".
^ Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011. PMID 10535969.
^ Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. doi:10.1016/S0168-9525(97)01269-9. PMID 9433137.
^ Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. doi:10.1128/MCB.18.8.4863. PMC 109071. PMID 9671495.
^ Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. doi:10.1093/hmg/8.6.959. PMID 10332027.
^ Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. doi:10.1023/A:1021246109101. PMID 12549823. S2CID 21864405.
^ Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365. PMID 16641098.
^ Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.

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Saccomanno L, Loushin C, Jan E, et al. (1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011. PMID 10535969.
Li ZZ, Kondo T, Murata T, et al. (2002). "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma". Jpn. J. Cancer Res. 93 (2): 167–77. doi:10.1111/j.1349-7006.2002.tb01255.x. PMC 5926958. PMID 11856480.
Wu JI, Reed RB, Grabowski PJ, Artzt K (2002). "Function of quaking in myelination: regulation of alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4233–8. Bibcode:2002PNAS...99.4233W. doi:10.1073/pnas.072090399. PMC 123631. PMID 11917126.
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Ichimura K, Mungall AJ, Fiegler H, et al. (2006). "Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH". Oncogene. 25 (8): 1261–71. doi:10.1038/sj.onc.1209156. PMC 2760128. PMID 16205629.
Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90. doi:10.1002/ajmg.b.30243. PMID 16342280. S2CID 11733591.
Aberg K, Saetre P, Jareborg N, Jazin E (2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365. PMID 16641098.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". The American Journal of Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.
Zhao L, Tian D, Xia M, et al. (2006). "Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI". J. Neurosci. 26 (44): 11278–86. doi:10.1523/JNEUROSCI.2677-06.2006. PMC 6674528. PMID 17079655.