PB-28
Names | |
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IUPAC name 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra- hydronaphthalen-1-yl)propyl]piperazine | |
Other names PB28 | |
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3D model (JSmol) |
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ChEBI |
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ChEMBL |
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ChemSpider |
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ECHA InfoCard | 100.215.826 |
IUPHAR/BPS |
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MeSH | C097775 |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C24H38N2O |
Molar mass | 370.57 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
PB-28[1] is an agonist of the sigma-2 receptor.[2][3][4][5][6]
It is derived from cyclohexylpiperazine.
References
- ^ Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). "New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives". J. Med. Chem. 39 (1): 176–82. doi:10.1021/jm950409c. PMID 8568804.
- ^ Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium. 40 (1): 23–8. doi:10.1016/j.ceca.2006.03.004. PMID 16687172.
- ^ Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). "Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer" (PDF). Mol. Cancer Ther. 5 (7): 1807–16. doi:10.1158/1535-7163.MCT-05-0402. PMID 16891467. S2CID 24267660.
- ^ Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R (July 2006). "Is the sigma2 receptor a histone binding protein?". Journal of Medicinal Chemistry. 49 (14): 4153–8. doi:10.1021/jm0600592. PMID 16821775.
- ^ Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R (December 2009). "Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)". Journal of Medicinal Chemistry. 52 (23): 7817–28. doi:10.1021/jm9007505. PMID 19842660.
- ^ Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA (February 2010). "Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer". ChemMedChem. 5 (2): 268–73. doi:10.1002/cmdc.200900402. PMID 20077462. S2CID 33532349.
External links
- PB28+compound at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Sigma receptor modulators
- Agonists: 3-PPP
- 4-PPBP
- 5-MeO-DMT
- Alazocine (SKF-10047)
- Amantadine
- Arketamine
- BD-737
- BD-1052
- Blarcamesine
- Captodiame
- Citalopram
- CGRPTooltip Calcitonin gene-related peptide
- Cloperastine
- Cocaine
- Cutamesine (SA-4503)
- Cyclazocine
- Dehydroepiandrosterone (DHEA) (prasterone)
- Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate)
- Dextrallorphan
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Dimemorfan
- Dimethyltryptamine (DMT)
- Ditolylguanidine (DTG)
- Donepezil
- Eliprodil
- Escitalopram
- Fabomotizole (afobazole)
- Fluoxetine
- Fluvoxamine
- Ifenprodil
- Igmesine (JO-1784)
- IPAB
- Ketamine
- L-687384
- MDMA (midomafetamine)
- Memantine
- Methamphetamine
- Methoxetamine
- Methylphenidate
- Nepinalone
- Neuropeptide Y
- Noscapine
- OPC-14523
- Opipramol
- Pentazocine
- Pentoxyverine (carbetapentane)
- PRE-084
- Pregnenolone
- Pregnenolone sulfate
- Pridopidine
- Racemethorphan (methorphan)
- Racemorphan (morphanol)
- UMB-23
- UMB-82
- Antagonists: 3-PPP
- AC-927
- BD-1008
- BD-1031
- BD-1047
- BD-1060
- BD-1063
- BD-1067
- BMY-14802 (BMS-181100)
- CM-156
- Dup-734
- E-5842
- E-52862 (S1RA)
- Haloperidol
- LR-132
- LR-172
- MS-377
- NE-100
- NPC-16377
- Panamesine (EMD-57455)
- PD-144418
- Pentazocine
- Progesterone
- Rimcazole (BW-234U)
- Sertraline
- SR-31742A
- Allosteric modulators: Phenytoin; Positive: Methylphenylpiracetam
- SOMCL-668
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCP
- 4C-T-2
- 4-IBP
- 4-IPBS
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Amitriptyline
- Azidopamil
- Chlorpromazine
- Clemastine
- Clomipramine
- Clorgiline
- D-Deprenyl
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Imipramine
- KCR-12-83.1
- Nemonapride
- Noribogaine
- RHL-033
- RS-67,333
- RTI-55
- Saffron
- Safinamide
- Selegiline
- Spipethiane
- Trifluoperazine
- W-18
- YKP10A
- Agonists: 3-PPP
- Arketamine
- BD-1047
- BD1063
- Ditolylguanidine (DTG)
- DKR-1005
- DKR-1051
- Haloperidol
- Ifenprodil
- Ketamine
- MDMA (midomafetamine)
- Methamphetamine
- OPC-14523
- Opipramol
- PB-28
- Phencyclidine
- Siramesine (Lu 28-179)
- UKH-1114
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCE
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Clemastine
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Nemonapride
- Nepinalone
- Noribogaine
- Pentazocine
- RS-67,333
- Safinamide
- TMATooltip 3,4,5-Trimethoxyamphetamine
- UMB-23
- UMB-82
- W-18
- Antagonists: AHD1
- AZ66
- Lamotrigine
- Naloxone
- SM-21
- UMB-100
- UMB-101
- UMB-103
- UMB-116
- YZ-011
- YZ-069
- YZ-185
- Allosteric modulators: SKF-83959
- Unknown/unsorted: 18-Methoxycoronaridine
- BMY-13980
- Butaclamol
- Caramiphen
- Carvotroline
- Chlorphenamine (chlorpheniramine)
- Chlorpromazine
- Cinnarizine
- Cinuperone
- Clocapramine
- Dezocine
- EMD-59983
- Hypericin (St. John's wort)
- Fluphenazine
- Gevotroline (WY-47384)
- Mepyramine (pyrilamine)
- Molindone
- Perphenazine
- Pimozide
- Proadifen
- Promethazine
- Propranolol
- Quinidine
- Remoxipride
- SL 82.0715
- SR-31747A
- Tiospirone (BMY-13859)
- Venlafaxine
See also: Receptor/signaling modulators
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