NDRG2

Protein-coding gene in humans
NDRG2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XMQ, 2XMR, 2XMS

Identifiers
AliasesNDRG2, SYLD, NDRG family member 2
External IDsOMIM: 605272; MGI: 1352498; HomoloGene: 22785; GeneCards: NDRG2; OMA:NDRG2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for NDRG2
Genomic location for NDRG2
Band14q11.2Start21,016,763 bp[1]
End21,070,872 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for NDRG2
Genomic location for NDRG2
Band14|14 C1Start51,905,271 bp[2]
End51,913,488 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • amygdala

  • right hemisphere of cerebellum

  • nucleus accumbens

  • putamen

  • hypothalamus

  • internal globus pallidus

  • caudate nucleus

  • prefrontal cortex

  • C1 segment
Top expressed in
  • muscle of thigh

  • wall of urinary bladder

  • mucosa of urinary bladder

  • transitional epithelium of urinary bladder

  • superior frontal gyrus

  • extensor digitorum longus muscle

  • cerebellar cortex

  • triceps brachii muscle

  • dentate gyrus of hippocampal formation granule cell

  • temporal muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • growth cone
  • nucleus
  • perinuclear region of cytoplasm
  • Golgi apparatus
  • cell projection
  • cytosol
  • extracellular exosome
  • cytoplasm
Biological process
  • negative regulation of smooth muscle cell proliferation
  • regulation of vascular endothelial growth factor production
  • negative regulation of cytokine production
  • nervous system development
  • multicellular organism development
  • cell differentiation
  • substantia nigra development
  • Wnt signaling pathway
  • negative regulation of ERK1 and ERK2 cascade
  • regulation of platelet-derived growth factor production
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57447

29811

Ensembl

ENSG00000165795

ENSMUSG00000004558

UniProt

Q9UN36

Q9QYG0

RefSeq (mRNA)
NM_001282211
NM_001282212
NM_001282213
NM_001282214
NM_001282215

NM_001282216
NM_016250
NM_201535
NM_201536
NM_201537
NM_201538
NM_201539
NM_201540
NM_201541
NM_001320329
NM_001354559
NM_001354562
NM_001354566
NM_001354567
NM_001354568
NM_001354569
NM_001354570
NM_001354558
NM_001354560
NM_001354561
NM_001354564
NM_001354565

NM_001145959
NM_013864

RefSeq (protein)
NP_001269140
NP_001269141
NP_001269142
NP_001269143
NP_001269144

NP_001269145
NP_001307258
NP_057334
NP_963293
NP_963294
NP_963831
NP_963832
NP_963833
NP_963834
NP_963835
NP_001341488
NP_001341491
NP_001341495
NP_001341496
NP_001341497
NP_001341498
NP_001341499
NP_001341487
NP_001341489
NP_001341490
NP_001341493
NP_001341494

NP_001139431
NP_038892
NP_001347193
NP_001347194
NP_001347195

NP_001347196
NP_001347197
NP_001347198
NP_001347199
NP_001347200
NP_001347201
NP_001347202
NP_001347203
NP_001347205

Location (UCSC)Chr 14: 21.02 – 21.07 MbChr 14: 51.91 – 51.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).[5][6]

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation[7]).[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165795 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004558 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399.
  6. ^ a b "Entrez Gene: NDRG2 NDRG family member 2".
  7. ^ Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC (September 2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
  8. ^ Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A (August 2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.

Further reading

  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
  • Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845. S2CID 24226208.
  • Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deng Y, Yao L, Chau L, et al. (2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
  • Choi SC, Kim KD, Kim JT, et al. (2003). "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells". FEBS Lett. 553 (3): 413–8. doi:10.1016/S0014-5793(03)01030-5. PMID 14572661.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
  • Mitchelmore C, Büchmann-Møller S, Rask L, et al. (2004). "NDRG2: a novel Alzheimer's disease associated protein". Neurobiol. Dis. 16 (1): 48–58. doi:10.1016/j.nbd.2004.01.003. PMID 15207261. S2CID 26992506.
  • Murray JT, Campbell DG, Morrice N, et al. (2005). "Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3". Biochem. J. 384 (Pt 3): 477–88. doi:10.1042/BJ20041057. PMC 1134133. PMID 15461589.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Hu XL, Liu XP, Lin SX, et al. (2005). "NDRG2 expression and mutation in human liver and pancreatic cancers". World J. Gastroenterol. 10 (23): 3518–21. doi:10.3748/wjg.v10.i23.3518. PMC 4576239. PMID 15526377.
  • Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
  • Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
  • Lusis EA, Watson MA, Chicoine MR, et al. (2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.


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