MLLT10

Protein-coding gene in the species Homo sapiens
MLLT10
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5DAG, 5DAH

Identifiers
AliasesMLLT10, AF10, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, histone lysine methyltransferase DOT1L cofactor, MLLT10 histone lysine methyltransferase DOT1L cofactor
External IDsOMIM: 602409; MGI: 1329038; HomoloGene: 20973; GeneCards: MLLT10; OMA:MLLT10 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for MLLT10
Genomic location for MLLT10
Band10p12.31Start21,524,646 bp[1]
End21,743,630 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MLLT10
Genomic location for MLLT10
Band2|2 A3Start18,055,237 bp[2]
End18,212,388 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • epithelium of colon

  • Achilles tendon

  • right testis

  • left testis

  • secondary oocyte

  • sperm

  • tibia

  • testicle

  • skin of thigh
Top expressed in
  • spermatocyte

  • genital tubercle

  • tail of embryo

  • secondary oocyte

  • primary oocyte

  • seminiferous tubule

  • zygote

  • neural layer of retina

  • spermatid

  • granulocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
  • metal ion binding
  • chromatin binding
  • nucleosome binding
  • histone binding
Cellular component
  • nucleoplasm
  • nucleus
  • cytosol
  • protein-containing complex
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8028

17354

Ensembl

ENSG00000078403

ENSMUSG00000026743

UniProt

P55197

O54826

RefSeq (mRNA)
NM_001009569
NM_001195626
NM_001195627
NM_001195628
NM_001195630

NM_004641
NM_001324296
NM_001324297

NM_001252560
NM_001252561
NM_010804

RefSeq (protein)
NP_001182555
NP_001182556
NP_001182557
NP_001182559
NP_001311225

NP_001311226
NP_004632

NP_001239489
NP_001239490
NP_034934

Location (UCSC)Chr 10: 21.52 – 21.74 MbChr 2: 18.06 – 18.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.[5][6]

Interactions

MLLT10 has been shown to interact with SS18.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078403 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026743 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. doi:10.1182/blood.V85.6.1435.bloodjournal8561435. PMID 7888665.
  6. ^ "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".
  7. ^ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. S2CID 2364045.

Further reading

  • Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides". Leukemia. 12 (9): 1404–10. doi:10.1038/sj.leu.2401109. PMID 9737689. S2CID 5821466.
  • Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V (2000). "Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation". J. Mol. Biol. 299 (2): 369–78. doi:10.1006/jmbi.2000.3766. PMID 10860745.
  • Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V (2000). "Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia". Br. J. Haematol. 110 (3): 547–51. doi:10.1046/j.1365-2141.2000.02212.x. PMID 10997963. S2CID 45898713.
  • de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. S2CID 2364045.
  • Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD (2002). "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex". Blood. 99 (1): 275–81. doi:10.1182/blood.V99.1.275. PMID 11756182.
  • Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384. S2CID 23631919.
  • Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM (2002). "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia". Cancer Genet. Cytogenet. 135 (2): 187–91. doi:10.1016/S0165-4608(01)00644-6. PMID 12127405.
  • Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E (2002). "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation". Mol. Cell. 10 (5): 1119–28. doi:10.1016/S1097-2765(02)00740-2. PMID 12453419.
  • Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM (2003). "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions". Mol. Cell. Biol. 23 (1): 119–30. doi:10.1128/MCB.23.1.119-130.2003. PMC 140655. PMID 12482966.
  • Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell. 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025. S2CID 15638573.


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