Lokivetmab
Monoclonal antibody
- QD11AH91 (WHO)
- veterinary use
- 1533403-95-0
Y
- 3D6091GOHH
Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs.[1] It acts against interleukin 31 (IL-31),[2] which is a cytokine involved in causing itchiness (pruritus).[2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks.[3]
The United States Department of Agriculture (USDA) approved lokivetmab (manufactured by Zoetis and sold under the trade name Cytopoint) in December 2016,[3] and it was approved by the European Medicines Agency in 2017.[4] Lokivetmab was the first monoclonal antibody to be approved for use in animals in the European Union.[4]
References
- ^ "Zoetis earns license for Cytopoint skin therapy". Veterinary Practice News. 4 January 2017. Retrieved 2018-07-06.
- ^ a b Marsella R, De Benedetto A (July 2017). "Atopic Dermatitis in Animals and People: An Update and Comparative Review". Veterinary Sciences. 4 (3): 37. doi:10.3390/vetsci4030037. PMC 5644664. PMID 29056696.
- ^ a b McKay L (13 July 2017). "Making a difference for dogs with atopic dermatitis: When to use Apoquel and when to use Cytopoint". dvm360.com. Retrieved 2018-07-07.
- ^ a b "First antibody therapy in veterinary medicine launched for dogs in the UK". The Veterinary Record. 181 (1): 6–7. July 2017. doi:10.1136/vr.j3147. PMID 28667135. S2CID 20166012.
External links
- "Lokivetmab". Drug Information Portal. U.S. National Library of Medicine.
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Other dermatological preparations (D11)
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- Antifungals
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- Lithium salts
- Topical corticosteroids (e.g., hydrocortisone)
- Abrocitinib
- Aminobenzoate potassium
- Androgens (e.g., testosterone)
- Brimonidine
- Caffeine
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- Collagen
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- Cromoglicic acid
- Deoxycholic acid
- Diclofenac
- Dupilumab
- Estrogens (e.g., estradiol)
- Glycopyrronium tosylate
- Hyaluronic acid
- Hydrogen peroxide
- Ivermectin
- Magnesium sulfate
- Metandienone
- Oxymetazoline
- Pregnenolone acetate
- Progestogens (e.g., progesterone)
- Povidone-iodine
- Tiratricol
- Tralokinumab
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