Interleukin-27 receptor
Type I cytokine receptor for interleukin-27
| interleukin 27 receptor, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL27RA | ||||||
| Alt. symbols | WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R | ||||||
| NCBI gene | 9466 | ||||||
| HGNC | 17290 | ||||||
| OMIM | 605350 | ||||||
| RefSeq | NM_004843 | ||||||
| UniProt | Q6UWB1 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.11 | ||||||
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| interleukin 6 signal transducer (gp130, oncostatin M receptor) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL6ST | ||||||
| Alt. symbols | GP130, CD130 | ||||||
| NCBI gene | 3572 | ||||||
| HGNC | 6021 | ||||||
| OMIM | 600694 | ||||||
| RefSeq | NM_002184 | ||||||
| UniProt | P40189 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q11 | ||||||
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The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1][2] and glycoprotein 130.[3]
IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4]
References
- ^ Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
- ^ Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature. 407 (6806): 916–20. Bibcode:2000Natur.407..916C. doi:10.1038/35038103. PMID 11057672. S2CID 205009928.
- ^ Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of Immunology. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
- ^ Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
External links
- Receptors,+Interleukin-27 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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(GPCRs)
| CC | |
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| CXC | |
| Other |
| 1-10 | |
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| 11-20 | |
| 21-27 |
| Type I |
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| Type II |
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