IL1RAPL2

Protein-coding gene in the species Homo sapiens
IL1RAPL2
Identifiers
AliasesIL1RAPL2, IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, interleukin 1 receptor accessory protein like 2
External IDsOMIM: 300277; MGI: 1913106; HomoloGene: 9681; GeneCards: IL1RAPL2; OMA:IL1RAPL2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for IL1RAPL2
Genomic location for IL1RAPL2
BandXq22.3Start104,566,199 bp[1]
End105,767,829 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for IL1RAPL2
Genomic location for IL1RAPL2
BandX|X F1Start136,471,357 bp[2]
End137,747,695 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • prefrontal cortex

  • right lobe of liver

  • skin of hip

  • Brodmann area 9

  • placenta

  • urinary bladder

  • gallbladder

  • primary visual cortex
Top expressed in
  • multiform layer of neocortex

  • internal granular layer

  • Purkinje cell

  • external pyramidal layer of neocortex

  • embryo

  • internal pyramidal layer of neocortex

  • barrel cortex

  • primary visual cortex

  • median eminence

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • interleukin-1, type II, blocking receptor activity
  • interleukin-1 receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • glutamatergic synapse
Biological process
  • central nervous system development
  • signal transduction
  • cytokine-mediated signaling pathway
  • regulation of presynapse assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26280

60367

Ensembl

ENSG00000189108

ENSMUSG00000059203

UniProt

Q9NP60

Q9ERS6

RefSeq (mRNA)

NM_017416

NM_030688

RefSeq (protein)

NP_059112

NP_109613

Location (UCSC)Chr X: 104.57 – 105.77 MbChr X: 136.47 – 137.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene.[5][6]

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189108 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059203 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639. S2CID 22262168.
  6. ^ a b "Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2".

Further reading

  • Grundtman C, Salomonsson S, Dorph C, et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies". Arthritis Rheum. 56 (2): 674–87. CiteSeerX 10.1.1.489.4969. doi:10.1002/art.22388. PMID 17265504.
  • Libra M, Mangano K, Anzaldi M, et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders". Oncol. Rep. 15 (5): 1305–8. doi:10.3892/or.15.5.1305. PMID 16596202.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system". Gene. 275 (2): 217–21. doi:10.1016/S0378-1119(01)00659-X. PMID 11587848.
  • Sana TR, Debets R, Timans JC, et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3". Genomics. 69 (2): 252–62. doi:10.1006/geno.2000.6328. PMID 11031108.
  • Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
  • Nagaoka H, Ozawa K, Matsuda F, et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16". Genomics. 22 (1): 189–97. doi:10.1006/geno.1994.1360. PMID 7959766.


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