GMEB2

Protein-coding gene in the species Homo sapiens
GMEB2
Identifiers
AliasesGMEB2, P79PIF, PIF79, GMEB-2, glucocorticoid modulatory element binding protein 2
External IDsOMIM: 607451; MGI: 2652836; HomoloGene: 8228; GeneCards: GMEB2; OMA:GMEB2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for GMEB2
Genomic location for GMEB2
Band20q13.33Start63,587,602 bp[1]
End63,627,101 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GMEB2
Genomic location for GMEB2
Band2|2 H4Start180,893,242 bp[2]
End180,929,828 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • buccal mucosa cell

  • thymus

  • mucosa of urinary bladder

  • mucosa of ileum

  • pancreatic ductal cell

  • granulocyte

  • right lobe of thyroid gland

  • tibialis anterior muscle

  • blood
Top expressed in
  • granulocyte

  • hand

  • otolith organ

  • utricle

  • cumulus cell

  • blood

  • medial ganglionic eminence

  • neural layer of retina

  • thymus

  • bone marrow
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • transcription coactivator activity
  • metal ion binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • regulation of transcription by RNA polymerase II
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26205

229004

Ensembl

ENSG00000101216

ENSMUSG00000038705

UniProt

Q9UKD1

P58929

RefSeq (mRNA)

NM_012384

NM_198169

RefSeq (protein)

NP_036516

NP_937812

Location (UCSC)Chr 20: 63.59 – 63.63 MbChr 2: 180.89 – 180.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.[5][6][7]

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101216 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038705 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.
  6. ^ Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.
  7. ^ a b "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

Further reading

  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Kaul S, Blackford JA, Chen J, et al. (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–27. doi:10.1210/me.14.7.1010. PMID 10894151.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–9. doi:10.1074/jbc.M112330200. PMID 11812797.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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