FUT6

Protein-coding gene in the species Homo sapiens

FUT6

Identifiers

Aliases

FUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI, fucosyltransferase 6

External IDs

OMIM: 136836; HomoloGene: 34780; GeneCards: FUT6; OMA:FUT6 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	5,830,408 bp^[1]
Band	19p13.3	End	5,839,722 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of pharynx

olfactory bulb

buccal mucosa cell

pancreatic ductal cell

nasal epithelium

mucosa of ileum

amniotic fluid

trachea

oral cavity

mucosa of transverse colon

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity alpha-(1->3)-fucosyltransferase activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity glycosyltransferase activity fucosyltransferase activity
Cellular component	integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome membrane Golgi membrane
Biological process	protein glycosylation L-fucose catabolic process fucosylation ceramide metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2528


n/a

Ensembl


ENSG00000156413


n/a

UniProt


P51993


n/a

RefSeq (mRNA)

NM_000150 NM_001040701 NM_001369502 NM_001369504 NM_001369505
NM_001381955 NM_001381956 NM_001381957 NM_001381958 NM_001381959


n/a

RefSeq (protein)

NP_000141 NP_001035791 NP_001356431 NP_001356433 NP_001356434
NP_001368884 NP_001368885 NP_001368886 NP_001368887 NP_001368888


n/a

Location (UCSC)

Chr 19: 5.83 – 5.84 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.^[3]^[4]^[5]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156413 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.
^ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
^ ^a ^b "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes". J. Biol. Chem. 267 (34): 24575–84. doi:10.1016/S0021-9258(18)35803-4. PMID 1339443.
Cameron HS, Szczepaniak D, Weston BW (1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". J. Biol. Chem. 270 (34): 20112–22. doi:10.1074/jbc.270.34.20112. PMID 7650030.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mollicone R, Reguigne I, Fletcher A, et al. (1994). "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)". J. Biol. Chem. 269 (17): 12662–71. doi:10.1016/S0021-9258(18)99927-8. PMID 8175676.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Borsig L, Imbach T, Höchli M, Berger EG (2000). "alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles". Glycobiology. 9 (11): 1273–80. doi:10.1093/glycob/9.11.1273. PMID 10536043.
Schnyder-Candrian S, Borsig L, Moser R, Berger EG (2000). "Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369–74. Bibcode:2000PNAS...97.8369S. doi:10.1073/pnas.97.15.8369. PMC 26954. PMID 10900002.
Kamińska J, Musielak M, Nowicka A, et al. (2001). "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase". Biochimie. 83 (8): 739–42. doi:10.1016/S0300-9084(01)01306-2. PMID 11530205.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kanoh A, Ota M, Narimatsu H, Irimura T (2003). "Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion". Biochem. Biophys. Res. Commun. 303 (3): 896–901. doi:10.1016/S0006-291X(03)00420-0. PMID 12670495.
Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis". Glycobiology. 14 (1): 13–25. doi:10.1093/glycob/cwh006. PMID 14514715.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948. S2CID 9731951.

Transferases: glycosyltransferases (EC 2.4)

2.4.1: Hexosyl-
transferases

Glucosyl-	Phosphorylase Starch Glycogen Cellobiose Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-Beta-glucan synthase Ceramide glucosyltransferase N-glycosyltransferase
Galactosyl-	Lactose synthase B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
Glucuronosyl-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hyaluronan synthase: HAS1 HAS2 HAS3
Fucosyl-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Mannosyl-	Dolichyl-phosphate-mannose-protein mannosyltransferase POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentosyl-
transferases

Ribose

ADP-ribosyltransferase	NAD⁺:diphthamide ADP-ribosyltransferase Diphtheria toxin Pseudomonas exotoxin NAD(P)⁺:arginine ADP-ribosyltransferase Pertussis toxin Cholera toxin Poly ADP ribose polymerase Sirtuin
Phosphoribosyltransferase	Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Uracil phosphoribosyltransferase Amidophosphoribosyltransferase
Other	Purine nucleoside phosphorylase: Thymidine phosphorylase ECGF1