DUSP3

DUSP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J4X, 1VHR, 3F81
Identifiers
Aliases	DUSP3, VHR, dual specificity phosphatase 3
External IDs	OMIM: 600183; MGI: 1919599; HomoloGene: 20870; GeneCards: DUSP3; OMA:DUSP3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,766,125 bp[1] End 43,778,977 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,861,969 bp[2] End 101,877,839 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii saphenous vein vastus lateralis muscle muscle of thigh myocardium of left ventricle thoracic diaphragm gastrocnemius muscle right ventricle apex of heart Top expressed in ascending aorta aortic valve substantia nigra muscle of thigh primary visual cortex superior frontal gyrus interventricular septum skeletal muscle tissue tunica media of zone of aorta vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity MAP kinase phosphatase activity hydrolase activity protein kinase binding protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein tyrosine phosphatase activity cytoskeletal protein binding receptor tyrosine kinase binding protein tyrosine kinase binding Cellular component cytosol nucleoplasm immunological synapse nucleus Biological process protein dephosphorylation positive regulation of mitotic cell cycle negative regulation of T cell receptor signaling pathway negative regulation of JNK cascade negative regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of T cell activation in utero embryonic development dephosphorylation negative regulation of cell migration negative regulation of epidermal growth factor receptor signaling pathway negative regulation of chemotaxis regulation of focal adhesion assembly cellular response to epidermal growth factor stimulus positive regulation of focal adhesion disassembly peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1845 72349 Ensembl ENSG00000108861 ENSMUSG00000003518 UniProt P51452 Q9D7X3 RefSeq (mRNA) NM_004090 NM_028207 RefSeq (protein) NP_004081 NP_082483 Location (UCSC) Chr 17: 43.77 – 43.78 Mb Chr 11: 101.86 – 101.88 Mb PubMed search [3] [4]
Wikidata
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Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.^[5][6]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.^[6]

Interactions

DUSP3 has been shown to interact with MAPK3^[7] and MAPK1.^[7]

References

Further reading