CENPK

Protein-coding gene in the species Homo sapiens
CENPK
Identifiers
AliasesCENPK, AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K
External IDsOMIM: 611502 MGI: 1926210 HomoloGene: 11035 GeneCards: CENPK
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CENPK
Genomic location for CENPK
Band5q12.3Start65,517,766 bp[1]
End65,563,168 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CENPK
Genomic location for CENPK
Band13|13 D1Start104,365,119 bp[2]
End104,388,900 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • ganglionic eminence

  • thymus

  • rectum

  • appendix

  • bone marrow

  • stromal cell of endometrium

  • trabecular bone

  • lymph node
Top expressed in
  • medial ganglionic eminence

  • primitive streak

  • vas deferens

  • spermatid

  • otic placode

  • Paneth cell

  • maxillary prominence

  • condyle

  • renal corpuscle

  • fossa
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
  • nucleus
  • nucleoplasm
  • chromosome, centromeric region
  • chromosome
  • kinetochore
Biological process
  • CENP-A containing chromatin assembly
  • kinetochore assembly
  • mitotic sister chromatid segregation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64105

60411

Ensembl

ENSG00000123219

ENSMUSG00000021714

UniProt

Q9BS16

Q9ESN5

RefSeq (mRNA)

NM_001267038
NM_022145
NM_001349367
NM_001349368
NM_001349369

NM_021790
NM_181061
NM_001377093
NM_001377094
NM_001377095

RefSeq (protein)

NP_001253967
NP_071428
NP_001336296
NP_001336297
NP_001336298

NP_068562
NP_851406
NP_001364022
NP_001364023
NP_001364024

Location (UCSC)Chr 5: 65.52 – 65.56 MbChr 13: 104.37 – 104.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein K is a protein that in humans is encoded by the CENPK gene.[5][6]

Interactions

CENPK has been shown to interact with SOX6.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123219 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021714 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.
  6. ^ "Entrez Gene: CENPK centromere protein K".
  7. ^ Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

External links

Further reading

  • Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (Jun 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
  • Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  • Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.


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