ABCC4

Protein-coding gene in the species Homo sapiens

ABCC4

Identifiers

Aliases

ABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4

External IDs

OMIM: 605250; MGI: 2443111; HomoloGene: 74563; GeneCards: ABCC4; OMA:ABCC4 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q32.1	Start	95,019,835 bp^[1]
Band	13q32.1	End	95,301,475 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 E4	Start	118,720,104 bp^[2]
Band	14\|14 E4	End	118,943,631 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

palpebral conjunctiva

secondary oocyte

buccal mucosa cell

corpus epididymis

kidney tubule

mucosa of urinary bladder

Epithelium of choroid plexus

epithelium of nasopharynx

mucosa of sigmoid colon

stromal cell of endometrium

Top expressed in

transitional epithelium of urinary bladder

conjunctival fornix

Epithelium of choroid plexus

olfactory epithelium

lacrimal gland

iris

ciliary body

retinal pigment epithelium

cornea

lumbar spinal ganglion

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding ATPase activity ATP binding 15-hydroxyprostaglandin dehydrogenase (NAD+) activity ATPase-coupled inorganic anion transmembrane transporter activity P-type ion transporter activity ATPase-coupled transmembrane transporter activity protein binding
Cellular component	integral component of membrane platelet dense granule membrane membrane plasma membrane basolateral plasma membrane integral component of plasma membrane
Biological process	prostaglandin secretion platelet degranulation response to organic cyclic compound response to organic substance positive regulation of smooth muscle cell proliferation response to organonitrogen compound transmembrane transport cilium assembly transport ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10257


239273

Ensembl


ENSG00000125257


ENSMUSG00000032849

UniProt


O15439


E9Q236

RefSeq (mRNA)


NM_001105515 NM_001301829 NM_001301830 NM_005845


NM_001033336 NM_001163675 NM_001163676

RefSeq (protein)


NP_001098985 NP_001288758 NP_001288759 NP_005836


NP_001028508 NP_001157147 NP_001157148

Location (UCSC)

Chr 13: 95.02 – 95.3 Mb

Chr 14: 118.72 – 118.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.^[5]^[6]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.^[7] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.^[8]

MRP4/ABCC4 expression is dysregulated in several cancers ^[9]^[10]^[11] and is also upregulated in peritoneal endometriosis.^[12]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032849 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ATP-binding cassette".
^ Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Research. 58 (13): 2741–7. PMID 9661885.
^ Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". The Journal of Clinical Investigation. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120.
^ Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, et al. (2003). "The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs". Proc Natl Acad Sci U S A. 100 (16): 9244–9. Bibcode:2003PNAS..100.9244R. doi:10.1073/pnas.1033060100. PMC 170903. PMID 12835412.
^ Ho LL, Kench JG, Handelsman DJ, Scheffer GL, Stricker PD, Grygiel JG, et al. (2008). "Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer". Prostate. 68 (13): 1421–9. doi:10.1002/pros.20809. PMID 18615486. S2CID 42717909.
^ Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, et al. (2011). "Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation". J Biol Chem. 286 (9): 6979–88. doi:10.1074/jbc.m110.166868. PMC 3044954. PMID 21205825.
^ Holla VR, Backlund MG, Yang P,Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.
^ Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2013). "Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)". Fertil Steril. 99 (7): 1965–1973.e2. doi:10.1016/j.fertnstert.2013.01.146. PMID 23472950.

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External links

ABCC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ABCC4 genome location and ABCC4 gene details page in the UCSC Genome Browser.